Protein biogenesis and quality control
in the secretory pathway
The Kopito laboratory seeks a molecular understanding of how cells maintain the fidelity of their proteomes. Unlike DNA, which can be repaired if damaged or incorrectly made, proteins cannot be mended. Instead, damaged or incorrectly synthesized proteins must be rapidly and efficiently destroyed lest they form toxic aggregates. Our laboratory use state-of-the-art cell biological, genetic and systems-level approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system.
RECENT NEWS
October 01, 2020
Two new postdocs join in 1 day! Welcome Celeste and Francesco!
August 10, 2019
Lab expedition to Angel Island!
July 01, 2019
Dara started a new position at Denali Therapeutics. We'll miss you, Dara!
June 06, 2019
Colin started a new job at Mantra Biosciences. Good luck, Colin!
February 24, 2020
Jada Cho Joins Kopito Lab team as Life Sciences Research Professional. Welcome, Jada!
January 06, 2019
Airila started a new job at Cepheid. Best of luck Airlia!
January 09, 2019
December 27, 2019
Chris started a new job at Novartis! Best of luck, Chris!
December 12, 2018
Dara's poster and talk were well received at the 2018 EMBO/ASCB meeting in San Diego
RECENT ARTICLES
Pataki et al, PNAS 2018
"Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors"
Leto et al, Mol Cell 2019
"Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation"
